This large and impressive wall in Rivington Street is by KaNO. Such a magnificent cartoon character in a very distinctive style, it should come as no surprise that KaNO freelances as a character designer for such studios as Warner Bros, Cartoon Network, and Hasbro.
KaNO was born and raised on the streets of New York and was influenced by cartoon characters on the TV. He then went on to study art and design and animation. His full biography can be found on his website, along with some fabulous galleries of studio and street art.
This really is a wonderful piece from a greatly talented artist.